4-Fluoroaniline → Methyl 2-cyano-3-[(4-fluorophenyl)amino]-3-(methylsulfanyl)-2-propenoate

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

0.5 g (4.5 mmol) of 4-fluoroaniline is thoroughly mixed with 0.91 g (4.5 mmol) of methyl 3,3-bis(methylthio)-2-cyanoacrylate (R. Gompper, W. Toepfl, Chem. Ber. 1962, 95, 2861-2870). The reaction mixture is heated at 150° C. for 2 h, resulting in a melt. After cooling, a pale solid is obtained and is washed several times with methanol. 0.68 g (55.7% of theory) of the desired product is obtained.

Herkunft & Nachweise