Potassium Carbonate → HCID 11725334, compound

Participants

Reaction Steps

A solution of 2-thienylmagnesium bromide was prepared from 2.27 g (0.094 mol) of magnesium and 15.4 g (0.094 mol) of 2-bromothiophene in 150 ml of THF. This solution was added to a solution of 11.34 g (0.043 mol) of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-oxo-2-thien-2-ylacetamide (Intermediate I-1) in 120 ml of THF. The mixture was stirred at room temperature for one hour, refluxed for one hour, cooled and treated with a saturated solution of ammonium chloride. The solution obtained was basified with a K2CO3 solution and extracted with CH2Cl2. The organic layer was washed with water and brine, dried over Na2SO4 and treated with activated carbon. The solution obtained was filtered trough Celite and solvents were evaporated to give a solid that was treated with ether and filtered to give 8.77 (58.5%) of the title product.

Provenance & Evidence