HRID1724673

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4716480

N-(pyridin-3-ylmethyl)ethanamine

C8H12N2

结构：COc1ccc(CN2C(=O)C(C)(c3cc(C(=O)O)ccc3Cl)c3cc(Cl)ccc32)c(OC)c1

HCID18752983

未命名化合物

2 次

PRODUCTS

生成物

结构：CCN(Cc1cccnc1)C(=O)c1ccc(Cl)c(C2(C)C(=O)N(Cc3ccc(OC)cc3OC)c3ccc(Cl)cc32)c1

HCID18753004

未命名化合物

PROCEDURE

实验过程

4-Chloro-3-[5-chloro-1-(2,4-dimethoxybenzyl)-3-methyl-2-oxoindolin-3-yl]benzoic acid, in the racemic form, is treated with N-ethyl-3-pyridylmethylamine (document WO 01/074775, example 201a) and b)). 4-Chloro-3-[5-chloro-1-(2,4-dimethoxybenzyl)-3-methyl-2-oxoindolin-3-yl]benzoic acid, in the racemic form, is described in the document WO 01/074775, in example 101. After silica chromatography, elution being carried out with a dichloromethane/methanol 90/10 mixture, the expected compound, in the racemic form, is obtained crystallized from methanol (white powder).

WORKUP

后处理

washAfter silica chromatography, elution

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2a8002671e604e149c2ab5f20833f384
来源数据集: uspto-grants-2009_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07488743B2
来源说明: uspto-grants-2009_02

反应 SMILES

[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][C:3]=1[C:11]1([CH3:33])[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([Cl:20])[CH:18]=2)[N:13]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][C:23]=2[O:30][CH3:31])[C:12]1=[O:32].[CH2:34]([NH:36][CH2:37][C:38]1[CH:39]=[N:40][CH:41]=[CH:42][CH:43]=1)[CH3:35]>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:36]([CH2:34][CH3:35])[CH2:37][C:38]2[CH:39]=[N:40][CH:41]=[CH:42][CH:43]=2)=[O:7])=[CH:4][C:3]=1[C:11]1([CH3:33])[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([Cl:20])[CH:18]=2)[N:13]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][C:23]=2[O:30][CH3:31])[C:12]1=[O:32]