Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 22245729 | HCID 22245729 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 22245786 | HCID 22245786 | 66% |
Reaction Steps
A mixture solution of 300 mg of the compound (23) obtained in the Example 23, 114 μl of benzoyl chloride and 206 μl of triethylamine in 5 ml of methylene chloride were stirred for 2 hours at 0° C. After the reaction, the solvent was removed and the obtained residue was purified by amine-coated silica gel (Fuji Silysia Chemical Ltd.; NH-DM1020) column chromatography (methylene chloride:ether=1:1) to give the above-mentioned compound (128) in 66% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07488738B2 |
|---|
| Source dataset | uspto-grants-2009_02 |
|---|
| ORD ID | ord-abad1e06f7ac439ba2f171c71f31a381 |
|---|
| Source note | uspto-grants-2009_02 |
|---|
