Acetyl chloride → HCID 69078908, compound

Participants

Reaction Steps

Cyclopropylcarbinol (15 ml) is cooled to 0° C. and acetyl chloride (1.37 ml) is added. After being subjected to agitation for 10 minutes at 0° C., D-serine (750 mg) is added and the solution is brought to reflux for 2 hours. The reaction mixture is concentrated, recovered with a potassium carbonate saturated solution and extracted with ethyl acetate. The organic phase is dried on MgSO4, filtered and concentrated. The product is recovered in a minimum of methanol and a hydrochloric acid solution 1N is added in ether. The solvent is vacuum evaporated to obtain the desired product as a brown solid (250 mg). Melting point: 112-118° C.

Provenance & Evidence