1H-Pyrrole-2-carboxylic acid, 5-methyl-, ethyl ester → HCID 57561739, compound

HRID 1724809Notes

Reaction equation

HRID 1724809 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]([CH3:11])=[CH:9][CH:10]=1)=[O:5])[CH3:2].[CH:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][C:13]=1[CH2:22][C:23](Cl)=[O:24]>>[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]([CH3:11])=[C:9]([C:23](=[O:24])[CH2:22][C:13]2[CH:14]=[CH:15][C:16]3[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:12]=2)[CH:10]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 965981H-Pyrrole-2-carboxylic acid, 5-methyl-, ethyl esterHCID 5881152-(2-Naphthyl)acetyl chloride

Product 1

HCID 57561739HCID 57561739, compound

Procedure

5-Methyl-4-(2-naphthalen-2-yl-acetyl)-1H-pyrrole-2-carboxylic acid ethyl ester (135) was synthesized from 5-methyl-1H-pyrrole-2-carboxylic acid ethyl ester (107) and naphthalen-2-yl-acetyl chloride following the procedure described in Example 32. Reaction Conditions: 1,2-dichloromethane/−40° C.→RT. Purification: no purification. LC/MS: 80%.

Workup

  1. customReaction Conditions
  2. customPurification
  3. customno purification

Sources & evidence

ORD record
ord-33bc0eade8424e53a54474dce0458612
Source dataset
uspto-grants-2009_02
Patent number
US07488747B2

Reaction notes

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