HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Pyrrole-2-carboxylic acid, 5-methyl-, ethyl ester → 5-Methyl-4-(2-phenyl-propionyl)-1H-pyrrole-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Pyrrole-2-carboxylic acid, 5-methyl-, ethyl ester | HCID 96598 | — |
| Reactant | Hydratropoyl chloride | HCID 2760403 | — |
| Product | 5-Methyl-4-(2-phenyl-propionyl)-1H-pyrrole-2-carboxylic acid ethyl ester | HCID 57435143 | — |
Reaction Steps
5-Methyl-4-(2-phenyl-propionyl)-1H-pyrrole-2-carboxylic acid ethyl ester (138) was synthesized from 5-methyl-1H-pyrrole-2-carboxylic acid ethyl ester (107) and 2-phenyl-propionyl chloride following the procedure described in Example 32. Reaction conditions: 1,2-dichloromethane/−40° C.→RT. Purification: no purification. LC/MS: 86%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07488747B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-6fc6d9adcb794fecbdaf115c0886d621 |
| Source note | uspto-grants-2009_02 |