Acetonitrile → HCID 59811134, compound

Participants

Reaction Steps

Dissolve methyl 4-chloro-2-methoxymethyl-7-[3-(trifluoromethyl)pyridin-2-yl]-[1,8]naphthyridine-3-carboxylate (212 mg, 0.52 mmol) in acetonitrile (5 mL) and add 4 drops 2M HCl (Et2O). Stir the mixture for 3 hours at room temperature. Filter off the resulting yellow precipitate to yield the title compound as its hydrochloride salt. MS 537.20 (M+1). 1H NMR δ (Free base, CDCl3) 9.91 (1H, s), 8.88 (1H, m), 8.16 (2H, m), 7.67-7.55 (4H, m), 7.12 (1H, d), 6.99 (1H, d), 4.42 (2H, s), 4.02 (3H, s), 3.95 (3H, s).

Provenance & Evidence