Sulfuric Acid → HCID 57561027, compound

Participants

Reaction Steps

Dissolve 7-[3-(trifluoromethyl)pyridin-2-yl]-4-{[5-(trifluoromethyl)pyridin-2-yl]amino}-1,8-naphthyridine-2-carbonitrile (25 mg, 0.054 mmol) in concentrated H2SO4 (2 mL) and stir the mixture overnight at ambient temperature. Pour the mixture onto ice and adjust the pH to about 7-8. Filter off the resulting precipitate to yield the title compound as an off-white solid. MS 479.02 (M+1). 1H NMR δ (CD3OD) 9.32 (1H, s), 9.10 (1H, d), 8.97 (1H, d), 8.71 (1H, s), 8.41 (1H, d), 8.05 (1H, d), 7.95 (1H, d), 7.82 (1H, m), 8.90 (1H,s), 7.44.

Provenance & Evidence