Nitric Acid → HCID 178494700, compound

HRID 1724850Notes

Reaction equation

HRID 1724850 reaction equation
[CH3:1][O:2][C:3](=[O:15])[C:4]1[C:9]([OH:10])=[CH:8][C:7]([OH:11])=[N:6][C:5]=1[CH2:12][O:13][CH3:14].[N+:16]([O-])([OH:18])=[O:17].O>CC(O)=O>[CH3:1][O:2][C:3](=[O:15])[C:4]1[C:9]([OH:10])=[C:8]([N+:16]([O-:18])=[O:17])[C:7]([OH:11])=[N:6][C:5]=1[CH2:12][O:13][CH3:14]

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 962WaterHCID 178494698HCID 178494698, compound

Product 1

HCID 178494700HCID 178494700, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
0 °C

Procedure

4,6-Dihydroxy-2-methoxymethyl-nicotinic acid methyl ester (15.9 g, 74.75 mmol) is dissolved in AcOH (60 mL) and cooled to 0° C. in an ice bath. Nitric acid (70%, 4.73 mL) is added dropwise. The resulting solution is stirred at room temperature overnight. Water (200 mL) is added to the mixture and a white precipitate forms. The precipitate is collected and dried in a vacuum oven to afford the title compound as a white solid.

Workup

  1. customThe precipitate is collected
  2. customdried in a vacuum oven

Sources & evidence

ORD record
ord-3a759a532e714addaf7b6ef96741877d
Source dataset
uspto-grants-2009_02
Patent number
US07488740B2

Reaction notes

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