HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 46203538, compound → HCID 178516410, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 46203538 | HCID 46203538 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | HCID 178516410 | HCID 178516410 | — |
Reaction Steps
Heat a solution of 2-methoxy-7-[3-(trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl)pyridin-2-yl]-[1,5]naphthyridin-4-amine (300 mg) in 33% hydrogen bromide in acetic acid (10 mL) at 100° C. for 18 hours. Evaporate to dryness, add saturated aqueous sodium bicarbonate (10 mL) and extract with EtOAc. Dry over Na2SO4, and concentrate under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07488740B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-315131018f234254a1bca35634fdf5f7 |
| Source note | uspto-grants-2009_02 |