Ammonium formate → HCID 46203540, compound

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Reaction Steps

Stir a mixture of 2-chloro-7-[3-(trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl) pyridin-2-yl]-[1,5]naphthyridin-4-amine (94 mg), ammonium formate (126 mg), 10% palladium on carbon (25 mg) in methanol (10 mL) at 50° C. for 2 hours. Cool, filter through Celite and evaporate to dryness. Purify by preparative thin layer chromatography, eluting with dichloromethane/methanol/ammonium hydroxide mixture to give the title compound. MS 436 (M+1). 1H NMR δ (CDCl3) 8.95-8.93 (2H, m), 8.63-8.57 (2H, m), 8.34-8.32 (1H, m), 8.26 (1H, s), 8.18 (1H, dd), 7.91 (1H, dd), 7.57-7.52 (2H, m).

Provenance & Evidence