HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → 2-(4-Methyl-3-nitrophenyl)-3-(trifluoromethyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | 2-p-Tolyl-3-trifluoromethyl-pyridine | HCID 22030373 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 2-(4-Methyl-3-nitrophenyl)-3-(trifluoromethyl)pyridine | HCID 22030128 | — |
Reaction Steps
To a solution of 2-p-tolyl-3-trifluoromethyl-pyridine (8.4 mmol) in H2SO4 (6 mL) cautiously add fuming HNO3 (2 ml). Stir the mixture for 1 hour at room temperature. Pour the mixture onto ice-water (30 mL), extract with EtOAc, wash with 1 N NaOH, dry over Na2SO4, and concentrate under vacuum to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07488740B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-01d5f8e6f90d4b64ba0975ba4540aeb7 |
| Source note | uspto-grants-2009_02 |