HCID 57561073, compound → HCID 46203234, compound

HRID 1724863Notes

Reaction equation

HRID 1724863 reaction equation
[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:15]([C:16]([F:19])([F:18])[F:17])=[CH:14][CH:13]=[CH:12][N:11]=2)=[CH:6][C:5]=1[N+:20]([O-])=O>CCO.[Pd]>[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:15]([C:16]([F:18])([F:19])[F:17])=[CH:14][CH:13]=[CH:12][N:11]=2)=[CH:6][C:5]=1[NH2:20]

Participants

4

Reactant 1

HCID 57561073HCID 57561073, compound

Product 1

HCID 46203234HCID 46203234, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Hydrogenate, at 50 psi, a mixture of 10% Pd-C (150 mg) and 2-nitro-4-(3-trifluoromethyl-pyridin-2-yl)-benzoic acid methyl ester (2 g) in 95% EtOH (100 mL). Filter through a celite pad and concentrate the filtrate to give the title compound.

Workup

  1. filtrationFilter through a celite pad
  2. concentrationconcentrate the filtrate

Sources & evidence

ORD record
ord-bc37a8b9aa064b438c6caa6174b25783
Source dataset
uspto-grants-2009_02
Patent number
US07488740B2

Reaction notes

Loading…