Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 1-[3-(Trifluoromethyl)pyridin-2-yl]ethan-1-one | HCID 53403137 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | Hydrogen Bromide | HCID 260 | — |
| Product | 2-Bromo-1-(3-(trifluoromethyl)pyridin-2-YL)ethanone | HCID 46204203 | — |
Reaction Steps
Dissolve 1-(3-trifluoromethyl-pyridin-2-yl)-ethanone (2.10 g, 11.1 mmol) in HBr (30% by wt in AcOH) (14 mL). Cool the mixture to 0° C. and add bromine (0.62 mL) drop wise. Allow the resulting solution to warm to room temperature and stir for 3 hours. Concentrate the reaction under reduced pressure to yield the title compound as its HBr salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07488740B2 |
|---|
| Source dataset | uspto-grants-2009_02 |
|---|
| ORD ID | ord-963385688ae841efa23fe9356a29bb73 |
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| Source note | uspto-grants-2009_02 |
|---|
