Cesium carbonate → 7-(3-Methylpyridin-2-yl)-n-(5-(trifluoromethyl)pyrazin-2-yl)-[1,8]naphthyridin-4-amine

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Reaction Steps

Heat a mixture of 5-chloro-2-(3-methylpyridin-2-yl)-[1,8]naphthyridine (51 mg, 0.2 mmol), 2-amino-5-trifluoromethylpyrazine (42.0 mg, 0.25 mmol), xantphos (11.6 mg, 0.02 mmol); Pd2(dba)3 (18.3 mg, 0.02 mmol)and Cs2CO3 (130 mg, 0.4 mmol) in dioxane (2.0 mL) at 100° C. for 20 hours. Cool the mixture, concentrate under vacuum, dilute with EtOAc/water (5.0 mL each), filter through celite, wash celite with EtOAc (2×5 mL) and dry the combined organic layers with MgSO4. Filter the dried extract and concentrate under vacuum to afford the crude product. Purify by preparative TLC using 2% MeOH/EtOAc as eluent to afford the title compound as a yellow solid. 1H NMR (400 MHZ, DMSO-D6) δ 10.6 (s, 1H), 9.04 (d, 1H, J=2.1 Hz), 9.0 (s,1H), 8.77 (s, 2H), 8.59 (d, 1H, J=1.6 Hz), 8.4 (s, 1H), 8.20 (d, 1H, J=2.2 Hz), 7.81(d, 1H, J=1.9 Hz), 7.42 (dd, 1H), 2.65 (s, 3H). MS=383.11 (M+H).

Provenance & Evidence