1,3-Dioxolane, 2-(bromomethyl)- → HCID 11583452, compound

HRID 1724901Notes

Reaction equation

HRID 1724901 reaction equation
[N:1]12[CH2:8][CH2:7][C:4]([C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[OH:10])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Br:23][CH2:24][CH:25]1[O:29][CH2:28][CH2:27][O:26]1>CC#N>[Br-:23].[O:26]1[CH2:27][CH2:28][O:29][CH:25]1[CH2:24][N+:1]12[CH2:6][CH2:5][C:4]([C:9]([OH:10])([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)([CH2:3][CH2:2]1)[CH2:7][CH2:8]2

Participants

4

Reactant 2

HCID 780681,3-Dioxolane, 2-(bromomethyl)-HCID 239923851-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol

Product 1

HCID 11583452HCID 11583452, compoundYield 12.4%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the general procedure outlined in Example 4, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0574 g, 0.196 mmol) and 2-(bromomethyl)-1,3-dioxolane (0.040 mL, 0.386 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.0112 g, 12.4%). EI-MS m/z 380(M+) Rt (1.64 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-cf815221de574c0d98c924c4de9465f5
Source dataset
uspto-grants-2009_02
Patent number
US07488827B2

Reaction notes

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