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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1724944Generated: October 30, 2026

Benzene, ((2-bromoethoxy)methyl)- → 4-(Hydroxy{bis[4-(methyloxy)phenyl]}methyl)-1-{2-[(phenylmethyl)oxy]ethyl}-1-azoniabicyclo[2.2.2]octane Bromide

https://huagongshe.com/reaction/1724944

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzene, ((2-bromoethoxy)methyl)-HCID 73833—
Reactant1-Azabicyclo[2.2.2]oct-4-yl{bis[4-(methyloxy)phenyl]}methanolHCID 68961638—
SolventAcetonitrileHCID 6342—
Product4-(Hydroxy{bis[4-(methyloxy)phenyl]}methyl)-1-{2-[(phenylmethyl)oxy]ethyl}-1-azoniabicyclo[2.2.2]octane BromideHCID 4262609546.7%

Reaction Steps

Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct-4-yl{bis[4-(methyloxy)phenyl]}methanol (0.0498 g, 0.141 mmol) and 2-bromoethyl phenylmethyl ether (0.0334 mL, 0.211 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.0374 g, 46.7%). EI-MS m/z 488(M+) Rt (1.94 min).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07488827B2
Source datasetuspto-grants-2009_02
ORD IDord-2209aaf89c964ed9b288f159cf0669ea
Source noteuspto-grants-2009_02