HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Bromophenyl)acetonitrile → 3-(4,4Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]-oxazin-6-yl)phenylacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Bromophenyl)acetonitrile | HCID 36023 | — |
| Reactant | (4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)boronic acid | HCID 10987806 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(4,4Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]-oxazin-6-yl)phenylacetonitrile | HCID 12094505 | — |
Reaction Steps
Prepared according to the procedure B from 3-bromophenylacetonitrile and (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl) boronic acid. White solid: mp 188-190° C. 1H-NMR (DMSO-d6) δ 10.33(s, 1H), 7.62 (m, 2H), 7.55 (m, 2H), 7.48 (d, 1H J=8.00 Hz), 7.33 (d, 1H, J=7.57 Hz), 6.99 (d, 1H, J=8.81 Hz) 4.09 (s, 2H), 1.67 (s, 6H); MS m/z 291(M−H). Anal. Calc. for (C18H16N2O2)2.0.3 H2O: C,72.61; H, 5.62; N, 9.41. Found: C, 73.00; H, 5.43; N, 8.81.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07488822B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-7e62743cde374cc09a1a94a6e3d62512 |
| Source note | uspto-grants-2009_02 |