Benzyl Bromide → 1-(1,1-Dimethylethyl) 2-(phenylmethyl) (2R)-1,2-pyrrolidinedicarboxylate

Participants

Reaction Steps

While cooling on ice, Boc-D-Pro-OH (17.2 g, 80 mmol) and benzyl bromide (14.3 ml, 120 mmol) were reacted in DMF (160 ml) in the presence of triethylamine (16.8 ml, 120 mmol) to obtain Boc-D-Pro-OBzl as an oily product. This product was reacted with 2 N HCl/dioxane (5 eq.) for 3 hours to obtain H-D-Pro-OBzl-HCl.

Provenance & Evidence