Guanidine → HCID 178513099, compound

Participants

Reaction Steps

Guanidine HCl (700 mmol, 66.5 mg) is dissolved in 1 mL of 0.5M NaOMe/methanol solution and rotated to dryness. The residue is subsequently dissolved in 400 uL dry DMSO. A white NaCl precipitate remained and the supernatant (free guanidine base in solution) is added to a vial containing [2-phenyl-5-(4-piperidin-1-yl-phenyl)-pyrrol-1-yl]-acetic acid methyl ester (170 mmol, 64 mg). The solution is agitated in a shaker at room temperature. The reaction is quenched with excess AcOH (75 uL), concentrated in vacuo. The residue is dissolved in a mixture of DMSO, MeOH and water (1.5 mL total) and purified by Gilson preparative HPLC system.

Provenance & Evidence