反应详情

温度

100 °C

A mixture of 1-(4-methoxy-phenyl)-4-phenyl-butane-1,4-dione (2.90 g, 10.8 mmol) and glycine 4 (1.62 g, 21.6 mmol) in 100 mL of glacial acetic acid is heated at 100° C. The reaction is monitored by TLC, when the starting material is consumed, the mixture is washed with 5% H2SO4 (200 mL) and then extracted with ethyl acetate (2×200 mL). The organics are combined, dried over sodium sulfate, filtered and concentrated to yield [2-(4-Methoxy-phenyl)-5-phenyl-pyrrol-1-yl]-acetic acid as a green solid (3.40 g, crude), characterized by LCMS (Obs: 308.54, Cal: 307.34).

1. customis consumed
2. washthe mixture is washed with 5% H2SO4 (200 mL)
3. extractionextracted with ethyl acetate (2×200 mL)
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated