Lithium Hydroxide → HCID 57423711, compound

Participants

Reaction Steps

To a solution of methyl(2-benzyl-5-phenyl-1H-pyrrol-1-yl)acetate (203 mg, 0.66 mmol) in THF (1 ml) was added aqueous 1N LiOH (1 ml) at room temperature. After 3 h stirring at room temperature, the reaction was quenched with H2O (10 ml). The aqueous was extracted with Et2O (2×10 ml). The aqueous was acidified with 1N HCl to pH˜3, extracted with EtOAc (3×15 ml). The combined organic extracts were washed with H2O (15 ml), brine (15 ml), dried (Na2SO4) and concentrated. The crude material was purified by chromatography (EtOAc/MeOH: 95/5) to provid the titled compound (185 mg, 96%) as a solid: mp 137-139° C.; MS (+) ES, 292 (M+H)+.

Provenance & Evidence