Glycine → HCID 57423718, compound

Participants

Reaction Steps

To a slurry of ˜1.0 mmol ethyl benzamide from Step 3 in 3 mL acetic acid was added 0.15 g (2.0 mmol) glycine. The reaction was mixed at 90-102° C. for 5.5 hr and allowed to cool. The solution was concentrated and and the residue was purified by 6Gilson preparative HPLC to afford 120 mg of [2-(4-ethylcarbamoyl-phenyl)-5-phenyl-pyrrol-1-yl]-acetic acid [5LC-MS data molecular ion and retention time): m/z 349 (M+H); 2.36 min] as a brown solid.

Provenance & Evidence