2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({5-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]pyridin-2-yl}amino)thiophene-3-carboxamide

HRID 172526Notes

Reaction equation

HRID 172526 reaction equation
[Cl:22][c:23]1[cH:24][cH:25][c:26](-[c:29]2[n:30][n:31][n:32]([CH2:34][CH2:35][OH:36])[cH:33]2)[cH:27][n:28]1.[NH2:1][c:2]1[s:3][c:4](-[c:10]2[c:11]([F:21])[cH:12][c:13]([C:17]([CH3:18])([CH3:19])[OH:20])[cH:14][c:15]2[F:16])[cH:5][c:6]1[C:7](=[O:8])[NH2:9]>>[NH:1]([c:2]1[s:3][c:4](-[c:10]2[c:11]([F:21])[cH:12][c:13]([C:17]([CH3:18])([CH3:19])[OH:20])[cH:14][c:15]2[F:16])[cH:5][c:6]1[C:7](=[O:8])[NH2:9])[c:23]1[cH:24][cH:25][c:26](-[c:29]2[n:30][n:31][n:32]([CH2:34][CH2:35][OH:36])[cH:33]2)[cH:27][n:28]1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595260902-[4-(6-Chloropyridin-3-yl)-1H-1,2,3-triazol-1-yl]ethanol

Product 1

HCID 595255835-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({5-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]pyridin-2-yl}amino)thiophene-3-carboxamide

Sources & evidence

ORD record
ord-94b8104906e14929bcc58634d5564fed
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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