反应详情

温度

50 °C

64.5 mg of 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-hydroxypropyl]-4-[4-(4-iodobutoxy)phenyl]azetidin-2-one are dissolved in 3 ml of methanol. 60.7 mg of 2-methylaminoethanesulfonic acid are then dissolved in 1 ml of water, and 30.4 mg of potassium carbonate are added. The reaction is stirred at 50° C. for 8 h. After concentration using a rotary evaporator at 40° C., the residue is passed over a reverse-phase cartridge (methanol). The resulting crude product is dissolved in hot methanol. The precipitate formed on cooling is filtered off, and the mother liquor is concentrated using a rotary evaporator. The product is obtained as an oil. C31H36F2N2O6S (602) MS (ESI): M+-18

1. concentrationAfter concentration
2. customa rotary evaporator at 40° C.
3. dissolutionThe resulting crude product is dissolved in hot methanol
4. customThe precipitate formed
5. temperatureon cooling
6. filtrationis filtered off
7. concentrationthe mother liquor is concentrated
8. customa rotary evaporator
9. customThe product is obtained as an oil