HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → HCID 273732, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester | HCID 17453 | — |
| Reactant | 1,3-Dihydro-1,3-dioxo-2H-isoindole-2-butanal | HCID 77150 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 273732 | HCID 273732 | 96% |
Reaction Steps
4-Phthalimidobutanal (120.9 g, 556 mmol) was then dissolved in 600 ml of CH2Cl2 and treated with methyl(triphenylphosphoranylidene)acetate (186 g, 556 mmol) in 600 ml of CH2Cl2. After 1 h the mixture was concentrated in vacuo and chromatographed in seven equal portions (Merck Kieselgel 60; 7×14 cm column; eluent 30% ethyl acetate in hexane) to give 145.6 g (96%) of methyl-6-phtalimidohex-2-enoate as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491520B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-b0e712ed96bc4ecd9c2d7d65781d4d2b |
| Source note | uspto-grants-2009_02 |