L-Leucine ethyl ester → HCID 86609796, compound

HRID 1725332Notes

Reaction equation

HRID 1725332 reaction equation
C([O:3][C:4](=[O:30])[C@H:5]([CH2:26][CH:27]([CH3:29])[CH3:28])[NH:6][C:7]([O:9][CH2:10][CH2:11][O:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][O:24][CH3:25])=[O:8])C.C(OC(=O)[C@H](CC(C)C)N)C>>[CH3:25][O:24][CH2:23][CH2:22][O:21][CH2:20][CH2:19][O:18][CH2:17][CH2:16][O:15][CH2:14][CH2:13][O:12][CH2:11][CH2:10][O:9][C:7]([NH:6][C@H:5]([C:4]([OH:30])=[O:3])[CH2:26][CH:27]([CH3:28])[CH3:29])=[O:8]

Participants

3

Reactant 2

HCID 75971L-Leucine ethyl esterHCID 86609797HCID 86609797, compound

Product 1

HCID 86609796HCID 86609796, compound

Procedure

Following the reaction in an analogous manner to Reference Example 2(3) and using N-((14-methoxy-3,6,9,12-tetraoxa-tetradecanyloxy)carbonyl-L-leucine ethyl ester in place of N-((3S)-tetrahydrofuran-3-yloxy)carbonyl)-L-leucine ethyl ester, there was obtained N-((14-methoxy-3,6,9,12-tetraoxa-tetradecanyloxy)carbonyl)-L-leucine as a colorless oil.

Workup

  1. customthe reaction in an analogous manner to Reference Example

Sources & evidence

ORD record
ord-7c6a02d4c11d443c8f2dac84e0717691
Source dataset
uspto-grants-2009_02
Patent number
US07491705B2

Reaction notes

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