Sodium Thiosulfate → HCID 57562391, compound

Participants

Reaction Steps

To a solution of ((1S)-1-((((1S)-1-benzyl-3-ethylamino-2-hydroxy-3-oxo-propyl)amino)carbonyl)-3-methylbutyl)carbamic acid 2-methoxyethyl ester (0.7 g, 1.6 mmol) in CH2Cl2 (70 mL) was added Dess-Martin periodinane (1.0 g, 2.4 mmol). The mixture was stirred at room temperature for 18 hours. Aqueous 10% Na2S2O3 (35 mL) and saturated aqueous NaHCO3 (35 mL) were added thereto, and the mixture was stirred at room temperature for 30 minutes. The organic layer was separated, washed with 1M HCl, saturated aqueous NaHCO3 and saturated aqueous NaCl, dried over MgSO4, and concentrated in vacuo. The residue was crystallized from EtOAc/hexane to give the title compound (0.62 g, 88%) as colorless crystals. M.p. 138.0-138.3° C.

Provenance & Evidence