反应详情

温度

85 °C

To a stirred solution of 2H-[2,7]naphthyridin-1-one (300 mg, 2.05 mmol) (Baldwin, J. J.; Mensler, K.; Ponticello, G. S, J. Org. Chem. 1978, 43(25), 4878-80.) in 98% sulfuric acid (2 ml), 60% nitric acid (0.30 ml) was added dropwise and the mixture was warmed to 85° C. during 3 h. Addition, of ice-cold water and basification to pH 7, gave a precipitate which was filtered and washed with ethyl ether to yield the title product as a yellow solid (87%).

1. additionAddition
2. customof ice-cold water and basification to pH 7, gave a precipitate which
3. filtrationwas filtered
4. washwashed with ethyl ether