反应详情

温度

50 °C

To a stirred solution of 100 mg (0.348 mmol) of 5-acetyl-2-ethyl-4-nitro-6-phenylpyridazin-3(2H)-one (Dal Piaz, V et al, J. Med. Chem. 1997, 40, 1417) in 5 ml of ethanol, 430 mg (4.524 mmol) of 2-aminopyrimidine was added. The resulting mixture was stirred at 50° C. during five days and the final product was collected by filtration and washed with diethylether to yield the title compound (42 mg, 35.6% yield).

1. filtrationthe final product was collected by filtration
2. washwashed with diethylether