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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1725547Generated: October 31, 2026

5-Quinolinamine, 2-methyl- → HCID 68487325, compound

https://huagongshe.com/reaction/1725547

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Quinolinamine, 2-methyl-HCID 148683—
Reactant5-acetyl-2-ethylnitro6-phenylpyridazin-3(2H)-oneHCID 10732015—
SolventEthanolHCID 702—
ProductHCID 68487325HCID 6848732557.7%

Reaction Steps

To a stirred solution of 100 mg (0.348 mmol) of 5-acetyl-2-ethyl-4-nitro-6-phenylpyridazin-3(2H)-one (Dal Piaz, V et al, J. Med. Chem. 1997, 40, 1417) in ethanol (5 mL), 5-amino-2-methylquinoline (83 mg, 0.522 mmol) was added. The resulting mixture was stirred at room temperature during three hours and the final product was collected by filtration and washed with diethylether to yield the title compound (80 mg, 57.6% yield).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07491722B2
Source datasetuspto-grants-2009_02
ORD IDord-889608fc8be74b379b06ad0d2edfed9b
Source noteuspto-grants-2009_02