HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Quinolinamine, 2-methyl- → HCID 68487325, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Quinolinamine, 2-methyl- | HCID 148683 | — |
| Reactant | 5-acetyl-2-ethylnitro6-phenylpyridazin-3(2H)-one | HCID 10732015 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 68487325 | HCID 68487325 | 57.7% |
Reaction Steps
To a stirred solution of 100 mg (0.348 mmol) of 5-acetyl-2-ethyl-4-nitro-6-phenylpyridazin-3(2H)-one (Dal Piaz, V et al, J. Med. Chem. 1997, 40, 1417) in ethanol (5 mL), 5-amino-2-methylquinoline (83 mg, 0.522 mmol) was added. The resulting mixture was stirred at room temperature during three hours and the final product was collected by filtration and washed with diethylether to yield the title compound (80 mg, 57.6% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491722B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-889608fc8be74b379b06ad0d2edfed9b |
| Source note | uspto-grants-2009_02 |