HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxy-5-nitroaniline → 1-(2-methoxy-5-nitrophenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxy-5-nitroaniline | HCID 7447 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Bis(2-chloroethyl)amine hydrochloride | HCID 522769 | — |
| Solvent | Chlorobenzene | HCID 7964 | — |
| Product | 1-(2-methoxy-5-nitrophenyl)piperazine | HCID 3783138 | 45.1% |
Reaction Steps
A mixture of 2-methoxy-5-nitro-phenylamine (16.8 g, 0.1 mol), bis-(2-chloro-ethyl)-amine hydrochloride (17.8 g, 0.1 mol) and potassium carbonate (69 g, 0.5 mol) in chlorobenzene (300 ml) was refluxed for 48 h, washed by water. The water phase was extracted with dichloromethane. The organic layers were combined, dried over sodium sulfate, purified with flash chromatography on silica gel (CH2Cl2/MeOH) to give the desired product, 1-(2-methoxy-5-nitrophenyl)piperazine (10.7 g, 45%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491727B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-bd125f31f09b4345910a67e34ca431b4 |
| Source note | uspto-grants-2009_02 |