HCID 23116641, compound → HCID 10072977, compound

HRID 1725558Notes

Reaction equation

HRID 1725558 reaction equation
[CH3:1][N:2]([CH3:15])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:4]=1.[F:16][C:17]1[CH:22]=[CH:21][C:20]([S:23]([N:26]2[CH2:31][CH2:30][CH:29]([CH2:32]OS(C3C=CC(F)=CC=3)(=O)=O)[CH2:28][CH2:27]2)(=[O:25])=[O:24])=[CH:19][CH:18]=1>>[F:16][C:17]1[CH:18]=[CH:19][C:20]([S:23]([N:26]2[CH2:31][CH2:30][CH:29]([CH2:32][N:12]3[CH2:13][CH2:14][N:9]([C:5]4[CH:4]=[C:3]([N:2]([CH3:15])[CH3:1])[CH:8]=[CH:7][CH:6]=4)[CH2:10][CH2:11]3)[CH2:28][CH2:27]2)(=[O:24])=[O:25])=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 23116641HCID 23116641, compoundHCID 86594848HCID 86594848, compound

Product 1

HCID 10072977HCID 10072977, compound

Procedure

Reaction of dimethyl-(3-piperazin-1-yl-phenyl)-amine and 4-fluoro-benzenesulfonic acid 1-(4-fluoro-benzenesulfonyl)-piperidin-4-ylmethyl ester as described in Example 1 gave the desired product, (3-{4-[1-(4-Fluoro-benzenesulfonyl)-piperidin-4-ylmethyl]-piperazin-1-yl}-phenyl)-dimethyl-amine.

Sources & evidence

ORD record
ord-580250bfebc645ed964ecb070305a5d5
Source dataset
uspto-grants-2009_02
Patent number
US07491727B2

Reaction notes

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