Methyl acetoacetate → HCID 135507431, compound

Participants

Reaction Steps

Utilizing the methods described in Example 1 the title compound was prepared from 2-hydroxy-benzimidic acid methyl ester (500 mg, 2.67 mmol), 2-(3-fluoro-phenyl)-ethylamine (330 μl, 2.6 mmol) and methyl acetoacetate (3.0 mL) yielding 160 mg (10%) of 3-[2-(3-fluoro-phenyl)-ethyl]-2-(2-hydroxy-phenyl)-6-methyl-3H-pyrimidin-4-one as a white solid after two purifications by flash chromatography on ODS silica gel eluting with methanol-water (4.5:6.5) followed by recrystallization from a large volume of toluene (100 mL).

Provenance & Evidence