HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (3R)-3-amino-1-(cyclopropylmethyl)hexahydro-2H-azepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl (3R)-1-(cyclopropylmethyl)-2-oxoazepan-3-ylcarbamate | HCID 58695830 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (3R)-3-amino-1-(cyclopropylmethyl)hexahydro-2H-azepin-2-one | HCID 57562531 | — |
Reaction Steps
Trifluoroacetic acid (5 mL) was added to a solution of tert-butyl (3R)-1-(cyclopropylmethyl)-2-oxoazepan-3-ylcarbamate (257 mg, 0.91 mmol) in dichloromethane (10 mL). After 1 h, the mixture was concentrated and azeotroped with dichloromethane (3×) to give the crude amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491713B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-ad37a55f6f6d44eb821c995588c22ab0 |
| Source note | uspto-grants-2009_02 |