Benzyl 4-(3-oxo-2,3-dihydropyridazin-4-yl)piperidine-1-carboxylate → HCID 57562526, compound

HRID 1725645Notes

Reaction equation

HRID 1725645 reaction equation
[O:1]=[C:2]1[C:7]([CH:8]2[CH2:13][CH2:12][N:11](C(OCC3C=CC=CC=3)=O)[CH2:10][CH2:9]2)=[CH:6][CH:5]=[N:4][NH:3]1>CCO.[Pd]>[NH:11]1[CH2:10][CH2:9][CH:8]([C:7]2[C:2](=[O:1])[NH:3][N:4]=[CH:5][CH:6]=2)[CH2:13][CH2:12]1

Participants

4

Reactant 1

HCID 67439720Benzyl 4-(3-oxo-2,3-dihydropyridazin-4-yl)piperidine-1-carboxylate

Product 1

HCID 57562526HCID 57562526, compoundYield 90.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of benzyl 4-(3-oxo-2,3-dihydropyridazin-4-yl)piperidine-1-carboxylate (0.90 mg, 2.88 mmol) and 10% Pd/C (500 mg) in EtOH (25 mL), was hydrogenated under a balloon for 4 h. The reaction was filtered through Celite with more EtOH and concentrated to afford the title compound (465 mg). MS 180.1 (M+1).

Workup

  1. filtrationThe reaction was filtered through Celite with more EtOH
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-4df944db378c491da2ae95f90b12ee4c
Source dataset
uspto-grants-2009_02
Patent number
US07491713B2

Reaction notes

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