1-Methyl-4-(piperidin-4-yl)piperazine → HCID 57529497, compound

HRID 1725748Notes

Reaction equation

HRID 1725748 reaction equation
[O:1]=[C:2]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@@H:18]([C:28]([OH:30])=O)[CH2:19][C:20]3[CH:21]=[N:22][C:23]([NH2:27])=[C:24]([CH3:26])[CH:25]=3)=[O:16])[CH2:11][CH2:10]2)[CH2:7][CH2:6][C:5]2[CH:31]=[CH:32][CH:33]=[CH:34][C:4]=2[NH:3]1.[CH3:35][N:36]1[CH2:41][CH2:40][N:39]([CH:42]2[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]2)[CH2:38][CH2:37]1>>[O:1]=[C:2]1[N:8]([CH:9]2[CH2:10][CH2:11][N:12]([C:15]([O:17][C@H:18]([CH2:19][C:20]3[CH:21]=[N:22][C:23]([NH2:27])=[C:24]([CH3:26])[CH:25]=3)[C:28]([N:45]3[CH2:44][CH2:43][CH:42]([N:39]4[CH2:38][CH2:37][N:36]([CH3:35])[CH2:41][CH2:40]4)[CH2:47][CH2:46]3)=[O:30])=[O:16])[CH2:13][CH2:14]2)[CH2:7][CH2:6][C:34]2[CH:33]=[CH:32][CH:31]=[CH:5][C:4]=2[NH:3]1

Participants

3

Reactant 2

HCID 7957071-Methyl-4-(piperidin-4-yl)piperazineHCID 67301680HCID 67301680, compound

Product 1

HCID 57529497HCID 57529497, compound

Procedure

Analogously to Example 1 h the product was obtained from 50 mg (0.11 mmol) of (R)-2-(6-amino-5-methyl-pyridin-3-yl)-1-carboxy-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate and 20 mg (0.11 mmol) 1-methyl-4-piperidin-4-yl-piperazine.

Workup

  1. customAnalogously to Example 1 h

Sources & evidence

ORD record
ord-1487f46e5bce4a0ab655f543ec50464a
Source dataset
uspto-grants-2009_02
Patent number
US07491717B2

Reaction notes

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