Ethyl 4-amino-1-piperidinecarboxylate → HCID 69055408, compound

Participants

Reaction Steps

To a stirred solution of ethyl-4-amino-piperidine carboxylate (5 g, 29 mmol) in toluene (100 mL) was added N,N-dimethylformamide azine (8.2 g) and catalytic amount of p-tolunesulfonic acid (0.3 g) and the resulting mixture was refluxed overnight. The mixture was cooled and washed with water, and the aqueous layer was evaporated and the residue was treated with dichloromethane (100 mL). The organic layer was dried over MgSO4, filtered and evaporated. The residue was purified on silica flash column eluting with 4% MeOH, 0.5% NH4OH in dichloromethane to give the desired ethyl 4-(4H-1,2,4-triazol-4-yl)piperidine-1-carboxylate (4.9 g).

Provenance & Evidence