HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl 4-(1H-imidazol-2-yl)-3,6-dihydropyridine-1(2H)-carboxylate → tert-butyl 4-(1H-imidazol-2-yl)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl 4-(1H-imidazol-2-yl)-3,6-dihydropyridine-1(2H)-carboxylate | HCID 69053296 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | tert-butyl 4-(1H-imidazol-2-yl)piperidine-1-carboxylate | HCID 17840015 | 99.2% |
Reaction Steps
A mixture of tert-butyl 4-(1H-imidazol-2-yl)-3,6-dihydropyridine-1(2H)-carboxylate (7.5 g) and palladium on carbon (10%, 1 g) in ethanol (150 mL) was hydrogenated at 30 psi overnight. The catalyst was removed by filtration through celite and the filtrate was evaporated to give tert-butyl 4-(1H-imidazol-2-yl)piperidine-1-carboxylate (7.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491737B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-b5455f3b58794e18851cd3d8ae8c03ae |
| Source note | uspto-grants-2009_02 |