HCID 86599037, compound → HCID 11246894, compound

HRID 1725795Notes

Reaction equation

HRID 1725795 reaction equation
[ClH:1].Cl.N[C@H]1CCN(C(C2C3C(=CC=CC=3)C=CC=2)CC2(O)CCCCC2)C1.[OH:28][C:29]1([CH:35]([C:51]2[C:60]3[C:55](=[CH:56][CH:57]=[CH:58][CH:59]=3)[CH:54]=[CH:53][CH:52]=2)[C:36]([N:38]2[CH2:42][CH2:41][C@H:40]([NH:43]C(=O)OC(C)(C)C)[CH2:39]2)=O)[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1>>[ClH:1].[ClH:1].[NH2:43][C@H:40]1[CH2:41][CH2:42][N:38]([CH2:36][CH:35]([C:29]2([OH:28])[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)[C:51]2[C:60]3[C:55](=[CH:56][CH:57]=[CH:58][CH:59]=3)[CH:54]=[CH:53][CH:52]=2)[CH2:39]1

Participants

3

Reactant 2

HCID 86599037HCID 86599037, compoundHCID 86599934HCID 86599934, compound

Product 1

HCID 11246894HCID 11246894, compound

Procedure

In an analogous manner to Example 1, step 2, 1-[2-[(3S)-3-aminopyrrolidin-1-yl]-(1-naphthyl)ethyl]cyclohexanol dihydrochloride was prepared from tert-butyl {(3S)-1-[(1-hydroxycyclohexyl)(1-naphthyl)acetyl]pyrrolidin-3-yl}carbamate MS (ESI) m/z 339; HRMS: calcd for C22H30N2O+H, 339.24364; found (ESI, [M+H]+), 339.2421.

Sources & evidence

ORD record
ord-09ea7a5f013045238093115e578cc66c
Source dataset
uspto-grants-2009_02
Patent number
US07491723B2

Reaction notes

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