HCID 68855900, compound → HCID 86599943, compound

HRID 1725796Notes

Reaction equation

HRID 1725796 reaction equation
[ClH:1].Cl.CN[C@@H]1CCN([CH2:10][CH:11]([C:22]2([OH:28])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)[C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)C1.C(O[C:34](=O)[NH:35][C@@H:36]1[CH2:40][CH2:39][N:38](C(=O)C(C2(O)CCCCC2)C2C=CC=C(C(F)(F)F)C=2)[CH2:37]1)(C)(C)C>>[ClH:1].[ClH:1].[CH3:34][NH:35][C@@H:36]1[CH2:40][CH2:39][N:38]([CH:27]2[CH2:26][CH2:25][CH2:24][CH2:23][C:22]2([CH:11]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:20])([F:21])[F:19])[CH:13]=2)[CH3:10])[OH:28])[CH2:37]1

Participants

3

Reactant 2

HCID 68855900HCID 68855900, compoundHCID 90986627HCID 90986627, compound

Product 1

HCID 86599943HCID 86599943, compound

Procedure

In an analogous manner to Example 13, step 2, 1-{2-[(3R)-3-(methylamino)pyrrolidin-1-yl]-1-[3-(trifluoromethyl)phenyl]ethyl}cyclohexanol dihydrochloride was prepared from tert-butyl((3R)-1-{(1-hydroxycyclohexyl)[3-(trifluoromethyl)phenyl]acetyl}pyrrolidin-3-yl)carbamate MS (ES) m/z 371.1; HRMS: calcd for C20H29F3N2O+H, 371.23102; found (ESI, [M+H]+), 371.2296.

Sources & evidence

ORD record
ord-27d872b0378c4e88a7b34d5f55311227
Source dataset
uspto-grants-2009_02
Patent number
US07491723B2

Reaction notes

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