HCID 68855477, compound → HCID 68853023, compound

HRID 1725805Notes

Reaction equation

[ClH:1].Cl.C1(CN2CCN(C3CCCCC3(C(C3C=CC(OC(F)(F)F)=CC=3)C)O)CC2)CCCCC1.[CH:36]1([CH2:42][N:43]2[CH2:48][CH2:47][N:46]([C:49](=O)[CH:50]([C:62]3([OH:68])[CH2:67][CH2:66][CH2:65][CH2:64][CH2:63]3)[C:51]3[CH:56]=[CH:55][C:54]([O:57][C:58]([F:61])([F:60])[F:59])=[CH:53][CH:52]=3)[CH2:45][CH2:44]2)[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1>>[ClH:1].[ClH:1].[CH:36]1([CH2:42][N:43]2[CH2:48][CH2:47][N:46]([CH2:49][CH:50]([C:62]3([OH:68])[CH2:63][CH2:64][CH2:65][CH2:66][CH2:67]3)[C:51]3[CH:52]=[CH:53][C:54]([O:57][C:58]([F:59])([F:60])[F:61])=[CH:55][CH:56]=3)[CH2:45][CH2:44]2)[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41]1

Participants

Reactant 2

HCID 68855477HCID 68855477, compound

HCID 86599948HCID 86599948, compound

Product 1

HCID 68853023HCID 68853023, compound

Procedure

In an analogous manner Example 1, step 2 1-{2-[4-(cyclohexylmethyl)piperazin-1-yl]-1-[4-(trifluoromethoxy)phenyl]ethylcyclohexanol dihydrochloride was prepared from 1-{2-[4-(cyclohexylmethyl)piperazin-1-yl]-1-[4-(trifluoromethoxy)phenyl]2-oxoethyl}cyclohexanol. MS(ESI) m/z 469 ([M+H]+). Anal Calcd for C26H39F3N2O22HCl: C, 57.67; H, 7.63; N, 5.17. Found: C, 57.23; H, 7.64; N, 4.86.

Sources & evidence

ORD record: ord-7261d6a908b24e18a135100fb660169a
Source dataset: uspto-grants-2009_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07491723B2

Reaction notes

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