Methanol → HCID 86599956, compound

HRID 1725811Notes

Reaction equation

HRID 1725811 reaction equation
[ClH:1].Cl.[CH3:3][C@H:4]1[N:9]([CH3:10])[CH2:8][CH2:7][N:6]([CH2:11][C@@H:12](C2(O)CCCCC2)[C:13]2[CH:18]=[CH:17][CH:16]=[C:15](OC(F)(F)F)[CH:14]=2)[CH2:5]1.Cl.Cl.C[C@H]1NCCN(C[C@@H](C2(O)CCCCC2)[C:42]2[CH:47]=[CH:46][CH:45]=[C:44]([O:48][C:49]([F:52])([F:51])[F:50])[CH:43]=2)C1.C[OH:61]>>[ClH:1].[ClH:1].[CH3:3][C@H:4]1[N:9]([CH3:10])[CH2:8][CH2:7][N:6]([CH2:11][CH:12]([CH:13]2[CH2:18][CH2:17][CH2:16][CH2:15][C@@H:14]2[OH:61])[C:42]2[CH:47]=[CH:46][CH:45]=[C:44]([O:48][C:49]([F:51])([F:52])[F:50])[CH:43]=2)[CH2:5]1

Participants

4

Reactant 3

HCID 887MethanolHCID 68852212HCID 68852212, compoundHCID 68854709HCID 68854709, compound

Product 1

HCID 86599956HCID 86599956, compound

Procedure

In an analogous manner to Example 24, 1-{(1S)-2-[(3R)-3,4-dimethylpiperazin-1-yl]-1-[3-(trifluoromethoxy)phenyl]ethyl}cyclohexanol dihydrochloride was prepared from 1-{(1S)-2-[(3R)-3-methylpiperazin-1-yl]-1-[3-(trifluoromethoxy)phenyl]ethyl}cyclohexanol (See Example 369). MS (ESI) m/z 401; HRMS: calcd for C21H31F3N2O2+H+, 401.24104; found (ESI, [M+H]+), 401.241. [α]D25=−13° (c=0.0085 g/mL, MeOH); CD=+@281 nm.

Sources & evidence

ORD record
ord-9ed9e2f6ba0e4a3e9f8b68c954622ac2
Source dataset
uspto-grants-2009_02
Patent number
US07491723B2

Reaction notes

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