HCID 21187623, compound → HCID 68853514, compound

HRID 1725813Notes

Reaction equation

HRID 1725813 reaction equation
[ClH:1].Cl.C1(O)CCCCC1.[CH2:10]([O:17][C:18]1[CH:23]=[CH:22][C:21]([CH:24]([C:40]2([OH:46])[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]2)[C:25]([N:27]2[CH2:31][CH2:30][C@@H:29]([NH:32]C(=O)OC(C)(C)C)[CH2:28]2)=O)=[CH:20][CH:19]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[ClH:1].[ClH:1].[NH2:32][C@@H:29]1[CH2:30][CH2:31][N:27]([CH2:25][CH:24]([C:40]2([OH:46])[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]2)[C:21]2[CH:20]=[CH:19][C:18]([O:17][CH2:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)=[CH:23][CH:22]=2)[CH2:28]1

Participants

3

Reactant 2

HCID 21187623HCID 21187623, compoundHCID 86599052HCID 86599052, compound

Product 1

HCID 68853514HCID 68853514, compound

Procedure

In an analogous manner to Example 1, step 2, 1-{2-(3R)-3-aminopyrrolidin-1-yl]-1-[4-(benzyloxy)phenyl]ethyl}cyclohexanol dihydrochloride was prepared from tert-butyl {(3R)-1-[[4-(benzyloxy)phenyl](1-hydroxycyclohexyl)acetyl]pyrrolidin-3-yl}carbamate. MS (ESI) m/z 395; HRMS: calcd for C25H34N2O2+H+, 395.26930; found (ESI, [M+H]+), 395.2684.

Sources & evidence

ORD record
ord-9b424428c49b4dc29fdde7bf23a4dfe1
Source dataset
uspto-grants-2009_02
Patent number
US07491723B2

Reaction notes

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