HCID 68852816, compound → HCID 69068635, compound

HRID 1725818Notes

Reaction equation

HRID 1725818 reaction equation
[ClH:1].Cl.C(OC1C=CC([CH:12]([C:20]2([OH:26])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[CH2:13][N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=CC=1OC(F)(F)F)C.[CH2:32]([O:34][C:35]1[CH:40]=[CH:39][C:38](C(C2(O)CCCCC2)CN2CCN(C(OC(C)(C)C)=O)CC2)=[CH:37][C:36]=1[O:63][C:64]([F:67])([F:66])[F:65])[CH3:33]>>[ClH:1].[ClH:1].[CH2:32]([O:34][C:35]1[CH:40]=[CH:39][C:38]([CH:13]([N:14]2[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)[CH2:12][C:20]2([OH:26])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]2)=[CH:37][C:36]=1[O:63][C:64]([F:65])([F:66])[F:67])[CH3:33]

Participants

3

Reactant 2

HCID 68852816HCID 68852816, compoundHCID 68855757HCID 68855757, compound

Product 1

HCID 69068635HCID 69068635, compound

Procedure

In an analogous manner to Example 135, step 4 1-{1-[4-ethoxy-3-(trifluoromethoxy)phenyl]-2-piperazin-1-ylethyl}cyclohexanol dihydrochloride was prepared from tert-butyl 4-[2-[4-(ethoxy)-3-(trifluoromethoxy)phenyl]-2-(1-hydroxycyclohexyl)ethyl]piperazine-1-carboxylate. MS (ES) m/z 417.1; HRMS: calcd for C21H31F3N2O3+H+, 417.23595; found (ESI, [M+H]+), 417.2354

Sources & evidence

ORD record
ord-d301fe5497c747f58972be413b22e4a6
Source dataset
uspto-grants-2009_02
Patent number
US07491723B2

Reaction notes

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