HCID 68851277, compound → HCID 86599961, compound

HRID 1725819Notes

Reaction equation

HRID 1725819 reaction equation
[ClH:1].Cl.C1(CCC2C=CC([CH:17]([C:25]3([OH:31])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[CH2:18][N:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)=CC=2)C=CC=CC=1.OC1(C([C:54]2[CH:59]=[CH:58][CH:57]=[CH:56][C:55]=2[CH2:60][CH2:61][C:62]2[CH:67]=[CH:66][CH:65]=[CH:64][CH:63]=2)CN2CCN(C(OC(C)(C)C)=O)CC2)CCCCC1>>[ClH:1].[ClH:1].[C:55]1([CH2:60][CH2:61][C:62]2[CH:63]=[CH:64][C:65]([CH:18]([N:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)[CH2:17][C:25]3([OH:31])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]3)=[CH:66][CH:67]=2)[CH:56]=[CH:57][CH:58]=[CH:59][CH:54]=1

Participants

3

Reactant 2

HCID 68851277HCID 68851277, compoundHCID 68855733HCID 68855733, compound

Product 1

HCID 86599961HCID 86599961, compound

Procedure

In an analogous manner to Example 135, step 4 1-{1-[4-(2-phenylethyl)phenyl]-2-piperazin-1-ylethyl]cyclohexanol dihydrochloride was prepared from tert-butyl 4-[(1-hydroxycyclohexyl)(2-phenylethyl phenyl)ethyl]piperazine-1-carboxylate. MS (ESI) m/z 393; HRMS: calcd for C26H36N2O+H+, 393.29004; found (ESI, [M+H]+), 393.2904.

Sources & evidence

ORD record
ord-ee990acfe35c4023bac46aa9605aef5e
Source dataset
uspto-grants-2009_02
Patent number
US07491723B2

Reaction notes

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