1-[1-{4-[(4-Bromo-2-fluorobenzyl)oxy]-3-chlorophenyl}-2-(4-methylpiperazin-1-yl)ethyl]cyclohexanol → HCID 68853905, compound

HRID 1725822Notes

Reaction equation

HRID 1725822 reaction equation
[Br:1][C:2]1[CH:32]=[CH:31][C:5]([CH2:6][O:7][C:8]2[CH:13]=[CH:12][C:11]([CH:14]([C:23]3([OH:29])[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)[CH2:15][N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)=[CH:10][C:9]=2[Cl:30])=[C:4]([F:33])[CH:3]=1.Cl.Cl.[Cl:36]C1C=C(C(C2(O)CCCCC2)CN2CCNCC2)C=CC=1OCC1C=CC=CC=1C(F)(F)F>>[ClH:30].[ClH:36].[Br:1][C:2]1[CH:32]=[CH:31][C:5]([CH2:6][O:7][C:8]2[CH:13]=[CH:12][C:11]([CH:14]([C:23]3([OH:29])[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)[CH2:15][N:16]3[CH2:17][CH2:18][N:19]([CH3:22])[CH2:20][CH2:21]3)=[CH:10][C:9]=2[Cl:30])=[C:4]([F:33])[CH:3]=1

Participants

3

Reactant 2

HCID 597012201-[1-{4-[(4-Bromo-2-fluorobenzyl)oxy]-3-chlorophenyl}-2-(4-methylpiperazin-1-yl)ethyl]cyclohexanolHCID 865994081-[1-(3-chloro-4-{[2-(trifluoromethyl)benzyl]oxy}phenyl)-2-piperazin-1-ylethyl]cyclohexanol Dihydrochloride

Product 1

HCID 68853905HCID 68853905, compound

Procedure

In an analogous manner to Example 24, 1-[1-{4-[(4-bromo-2-fluorobenzyl)oxy]-3-chlorophenyl}-2-(4-methylpiperazin-1-yl)ethyl]cyclohexanol was prepared from 1-(1-{4-[(4-bromo-2-fluorobenzyl)oxy]-3-chlorophenyl}-2-piperazin-1-ylethyl)cyclohexanol dihydrochloride (See Example 421). MS (ESI) m/z 539; HRMS: calcd for C26H33BrClFN2O2+H+, 539.14707; found (ESI, [M+H]+), 539.1453.

Sources & evidence

ORD record
ord-93e282cc225642ef9c92a2d882073c91
Source dataset
uspto-grants-2009_02
Patent number
US07491723B2

Reaction notes

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