HCID 68852213, compound → HCID 69072712, compound

HRID 1725823Notes

Reaction equation

HRID 1725823 reaction equation
[ClH:1].Cl.NC1CCN([CH2:10][CH:11](C2(O)CCCCC2)[C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]3[CH:29]=[CH:28][C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH:21]=3)=[C:14]([Cl:30])[CH:13]=2)CC1.[Cl:38]C1C=[C:41]([CH:57](C2(O)CCCCC2)[C:58]([N:60]2[CH2:65][CH2:64][CH:63]([NH:66]C(=O)OC(C)(C)C)[CH2:62][CH2:61]2)=O)[CH:42]=[CH:43][C:44]=1[O:45]CC1C=CC2C(=CC=CC=2)C=1>>[ClH:30].[ClH:38].[NH2:66][CH:63]1[CH2:62][CH2:61][N:60]([CH:58]2[CH2:57][CH2:41][CH2:42][CH2:43][C:44]2([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]3[CH:29]=[CH:28][C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH:21]=3)=[C:14]([Cl:1])[CH:13]=2)[OH:45])[CH2:65][CH2:64]1

Participants

3

Reactant 2

HCID 68852213HCID 68852213, compoundHCID 86599966HCID 86599966, compound

Product 1

HCID 69072712HCID 69072712, compound

Procedure

In an analogous manner to Example 1, step 2 1-{2-(4-aminopiperidin-1-yl)-1-[3-chloro-4-(2-naphthylmethoxy)phenyl]ethyl}cyclohexanol dihydrochloride was prepared from tert-butyl {1-[[3-chloro-4-(2-naphthylmethoxy)phenyl](1-hydroxycyclohexyl)acetyl]piperidin-4-yl}carbamate. MS (ESI) m/z 493; HRMS: calcd for C30H37ClN2O2+H+, 493.26163; found (ESI, [M+H]+), 493.2599.

Sources & evidence

ORD record
ord-db83db856f4248f185498e6e4314c21b
Source dataset
uspto-grants-2009_02
Patent number
US07491723B2

Reaction notes

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