HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-6-{[(tert-butoxy)carbonyl]amino}-2-methylbenzoic acid → 6-Amino-3-bromo-2-methylbenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-6-{[(tert-butoxy)carbonyl]amino}-2-methylbenzoic acid | HCID 68866447 | — |
| Solvent | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Product | 6-Amino-3-bromo-2-methylbenzoic acid | HCID 15885809 | — |
Reaction Steps
A solution of Example 104B (300 mg, 0.9 mmol) in anhydrous 4N HCl/dioxane solution (10 mL) was stirred for 2 hours and concentrated to provide the desired product as the hydrochloride salt. MS (ESI(−)) m/e 228, 230 (M−H)−; 1H NMR (300 MHz, DMSO-d6) δ 7.34 (d, 1H), 6.66 (d, 1H), 4.44 (br s, 3H), 2.34 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491718B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-d5e6e5bf28b0497f9bceccbfb3eba7e6 |
| Source note | uspto-grants-2009_02 |